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accompanied by spasticity, increased re exes, and an extensor plantar re ex (Babinski sign); exceptionally, a small lesion of the motor cortex will not result in spasticity In either event, nerve conduction studies are normal In acute diseases of the lower motor neurons, the tendon re exes are reduced or abolished, but atrophy may not appear for several weeks Hence, before reaching an anatomic diagnosis, one must take into account the mode of onset and duration of the disease Monoplegia with Muscular Atrophy This is more frequent than monoplegia without muscular atrophy Long-continued disuse of one limb may lead to atrophy, but it is usually of lesser degree than atrophy due to lower motor neuron disease (denervation atrophy) In disuse atrophy, the tendon re exes are retained and nerve conduction studies are normal With denervation of muscles, there may be visible fasciculations and reduced or abolished tendon re exes in addition to paralysis If the limb is partially denervated, the electromyogram shows reduced numbers of motor unit potentials (often of large size) as well as fasciculations and brillations The location of the lesion (in nerves, spinal roots, or spinal cord) can usually be determined by the pattern of weakness, by the associated neurologic symptoms and signs, and by special tests magnetic resonance imaging (MRI) of the spine, examination of the cerebrospinal uid (CSF), and electrical studies of nerve and muscle A complete atrophic brachial monoplegia is uncommon; more often, only parts of a limb are affected When present in an infant, it should suggest brachial plexus trauma from birth; in a child, poliomyelitis or other viral infection of the spinal cord; and in an adult, poliomyelitis, syringomyelia, amyotrophic lateral sclerosis, or a brachial plexus lesion Crural (leg) monoplegia is more frequent than brachial monoplegia and may be caused by any lesion of the thoracic or lumbar cord ie, trauma, tumor, myelitis, multiple sclerosis, progressive muscular atrophy, late radiation effect, etc These disorders rarely cause severe atrophy; neither does infarction in the territory of the anterior cerebral artery A prolapsed intervertebral disc and the several varieties of mononeuropathy almost never paralyze all or most of the muscles of a limb The effects of a centrally prolapsed disc or other compressive lesion of the cauda equina are rarely con ned to one leg However, a unilateral retroperitoneal tumor or hematoma may paralyze the leg by compressing the lumbosacral plexus The mode of onset and temporal course differentiate these diseases.

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5 6 7 8

Summary

The ventrobasal thalamic complex and the ventroposterior group of nuclei project to two main cortical areas: the primary sensory (postcentral) cortex (a small number terminate in the precentral cortex) and the upper bank of the sylvian ssure These cortical areas are described more fully in Chap 9, but it can be stated here that they are concerned mainly with the reception of tactile and proprioceptive stimuli and with all discriminative sensory functions, including pain The extent to which either cortical area is activated by thermal and painful stimuli is uncertain Certainly, stimulation of these (or any other) cortical areas in a normal, alert human being does not produce pain The intralaminar nuclei, which also project to the hypothalamus, amygdaloid nuclei, and limbic cortex, probably mediate the arousal and affective aspects of pain and the autonomic responses The thalamic projections to the primary sensory cortex that is distributed mainly along the postcentral gyrus of the anterior pa-

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With damage to tissue, there is a release of proteolytic enzymes, which act locally on tissue proteins to liberate substances that excite peripheral nociceptors These pain-producing substances which include histamine, prostaglandins, serotonin, and similar polypeptides as well as potassium ions elicit pain when they are injected intra-arterially or applied to the base of a blister Other pain-producing substances such as kinins are released from sensory nerve endings or are carried there by the circulation Also, vascular permeability is increased by these substances In addition, direct stimulation of nociceptors releases polypeptide mediators that enhance pain perception The best-studied of these is substance P, which is released from the nerve endings of C bers in the skin during peripheral nerve stimulation It causes erythema by dilating cutaneous vessels and edema by releasing histamine from mast cells; it also acts as a chemoattractant for leukocytes This reaction, called neurogenic in ammation by White and Helme, is mediated by antidromic action potentials from the small nerve cells in the spinal ganglia and is the basis of the axon re ex of Lewis; the re ex is abolished in peripheral nerve diseases and can be studied electrophysiologically as an aid to clinical localization

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