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funds often outperform their managed counterparts because investors follow the index rather than managing and trading within the fund Index mutual funds have their disadvantages in that the net asset value (NAV) is calculated at the end of the day, and all transaction orders for that day are completed based on the end of day NAV Mutual funds may not be traded intraday or sold short, and they do not have options associated with them Some index funds allow small, regular, individual investments into the funds; but in general index funds are primarily funded by institutional money The advantage to index mutual funds for individual and business investors is the long-term nature of the funds Index funds are designed to as closely as possible represent the performance of the underlying index Commonly the fees are not terribly out of line in comparison to managed mutual funds which may be attempting to outperform the market and have much larger expenses Exchange-traded funds (ETFs) We get into ETF trading a little further in the chapter, but the exchange-traded fund is another method of index investing ETFs, like index mutual funds, are often track index securities, but the ETF is traded like a stock and will generate a commission ETF shares can be traded intraday and have options capability that index funds do not Futures markets The major indices have futures contracts that are traded on the Chicago Mercantile Exchange (CME), the Chicago Board of Trade (CBOT), and the Chicago Board Options Exchange (CBOE) If you are working with a large portfolio or a larger-scale investment into the indices, the futures market offers signi cant bang

neuropathy, eg, chronic demyelinative motor neuropathy with multifocal conduction block Other useful laboratory procedures are (1) biochemical tests to identify metabolic, nutritional, or toxic states; (2) CSF examination (increase in protein and in cells that indicate radicular or meningeal involvement); (3) nerve and muscle biopsy; (4) measurement of immunoglobulins and antineural antibodies that relate to immune-mediated neuropathies; (5) genetic testing for several of the inherited neuropathies; and (6) nerve biopsy Once having established that the patient has a disease of the peripheral nerves and having ascertained its clinical and electrophysiologic pattern and time course, one is usually able to determine its nature This is accomplished most readily by allocating the case in question to one of the categories in Table 46-2, wherein the peripheral nerve diseases are classi ed syndromically according to their mode of evolution and clinical presentation Again, by categorizing the neuropathic syndrome in this way by topography and time course and by motor or sensory predominance, only a limited number of diagnoses are possible These are discussed in the sections that follow Our use of the terms acute, subacute, and chronic neuropathy must be explained By acute we mean evolution in terms of days and by subacute, weeks Chronic is divided into two groups: one in which the neuropathy has progressed for a period of several months to a few years, and another in which progression is over several years, most of which prove to have a genetic cause It can be restated that these temporal properties are, with the topographic pattern, the main determinants in the categorization of neuropathy Diseases of the peripheral nerves are considered in a more comprehensive fashion in the two-volume monograph Peripheral Neuropathy, edited by Dyck and colleagues Also recommended are more concise monographs on this subject by Schaumburg and associates and by Asbury and Thomas and the atlas on the pathology of peripheral nerve by King.

You can also see that even though the revenue was much lower in April than in March, the difference in revenue versus operating costs is about the same Therefore, some fixed costs are probably in the operating costs to keep them at such a high level You can also see that after about the $60,000 level, operating costs are going to start eating into margins due to the fixed costs (probably) This illustration shows how easy it is to get additional information out of this data using this chart type versus the other chart type, which you have to struggle just to read Yes, the column chart type might seem very straightforward and boring, but the business user will thank you for its simplicity They want to get the data quickly and effectively, not take a test in graphic design So, use the appropriate chart type in your design

If one looks critically at patients who seek medical help because of incapacitating exhaustion, lassitude, and fatigability (sometimes incorrectly called weakness ), it is evident that the most commonly overlooked diagnoses are anxiety and depression The correct conclusion can usually be reached by keeping these illnesses in mind as one elicits the history from patient and family Dif culty arises when symptoms of the psychiatric illness are so inconspicuous as not to be appreciated; one comes then to suspect the diagnosis only by having eliminated the common medical causes Repeated observation may bear out the existence of an anxiety state or gloomy mood, as the patient resists rehabilitation Strong reassurance in combination with a therapeutic trial of antianxiety or antidepressant drugs may suppress symptoms of which the patient was barely aware, thus clarifying the diagnosis The constitutionally asthenic individual, described earlier, is recognized by the characteristic lifelong behavioral pattern disclosed by his biography The best that can be done is to assist the patient in adjusting to the adverse circumstances that have brought him under medical surveillance Tuberculosis, brucellosis, Lyme disease, hepatitis, subacute bacterial endocarditis, mycoplasmal pneumonia, EBV, cytomegalovirus (CMV), coxsackie B and other viral infections, and malaria, hookworm, giardiasis, and other parasitic infections need to be considered in the differential diagnosis and an inquiry made for their characteristic symptoms, signs, and, when appropriate, laboratory ndings; such are infrequently found There should also be a search for anemia, azotemia, chronic in ammatory disease such as temporal arteritis polymyalgia rheumatica (sedimentation rate), and occult tumor; an endocrine survey (thyroid, calcium, and cortisol

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